Joint longitudinal and survival-cure models in tumour xenograft experiments

Joint longitudinal and survival-cure models in tumour xenograft experiments.

In tumour xenograft experiments, treatment regimens are administered, and the tumour volume of each individual is measured repeatedly over time. Survival data are recorded because of the death of some individuals during the observation period. Also, cure data are observed because of a portion of individuals who are completely cured in the experiments. When modelling these data, certain constrai...

Joint Longitudinal and Survival-cure Models with Constrained Parameters in Tumour Xenograft Experiments

Joint Modeling of Longitudinal and Cure-survival Data.

This article presents semiparametric joint models to analyze longitudinal measurements and survival data with a cure fraction. We consider a broad class of transformations for the cure-survival model, which includes the popular proportional hazards structure and the proportional odds structure as special cases. We propose to estimate all the parameters using the nonparametric maximum likelihood...

Joint Longitudinal-survival-cure Models and Their Application to Prostate Cancer

Many scientific investigations generate both longitudinal data and survival data. Methods for the combined analysis of both kinds of data have been developed in recent years, with the main emphasis being on modeling and estimation. In cancer research it is common for there to be long term survivors or cured patients and methods have been developed to analyze such data. In this article, we revie...

Bayesian Sample Size Determination for Joint Modeling of Longitudinal Measurements and Survival Data

A longitudinal study refers to collection of a response variable and possibly some explanatory variables at multiple follow-up times. In many clinical studies with longitudinal measurements, the response variable, for each patient is collected as long as an event of interest, which considered as clinical end point, occurs. Joint modeling of continuous longitudinal measurements and survival time...